{"id":541,"date":"2025-05-27T04:25:29","date_gmt":"2025-05-27T04:25:29","guid":{"rendered":"https:\/\/madinslovenia.org\/?p=541"},"modified":"2025-05-27T04:25:31","modified_gmt":"2025-05-27T04:25:31","slug":"uporaba-antidepresivov-pri-ljudeh-z-depresivnimi-simptomi-povecuje-tveganje-za-razvoj-manije-in-bipolarne-motnje","status":"publish","type":"post","link":"https:\/\/madinslovenia.org\/?p=541","title":{"rendered":"Uporaba antidepresivov pri ljudeh z depresivnimi simptomi pove\u010duje tveganje za razvoj manije in bipolarne motnje"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u010clanek z naslovom &#8220;Do antidepressants increase the risk of mania and bipolar disorder in people with depression? A retrospective electronic case register cohort study&#8221; (PMCID: PMC4679886) preu\u010duje povezavo med uporabo antidepresivov in kasnej\u0161im razvojem manije ali bipolarne motnje pri posameznikih z depresijo.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Klju\u010dne ugotovitve:<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Obseg \u0161tudije:<\/strong> V raziskavo je bilo vklju\u010denih 21.012 odraslih pacientov z diagnozo depresije, ki so se med aprilom 2006 in marcem 2013 zdravili v okviru South London and Maudsley NHS Trust (SLaM).<\/li>\n\n\n\n<li><strong>Incidenca manije\/bipolarne motnje:<\/strong> Skupna stopnja pojavnosti manije ali bipolarne motnje je zna\u0161ala 10,9 na 1000 oseb-let, pri \u010demer je bila najvi\u0161ja incidenca opa\u017eena pri starostni skupini med 26 in 35 leti (12,3 na 1000 oseb-let).<\/li>\n\n\n\n<li><strong>Povezava z antidepresivi:<\/strong> Predhodno zdravljenje z antidepresivi je bilo povezano s pove\u010dano incidenco manije ali bipolarne motnje, ki se je gibala med 13,1 in 19,1 na 1000 oseb-let.<\/li>\n\n\n\n<li><strong>Specifi\u010dna zdravila:<\/strong> Multivariatna analiza je pokazala statisti\u010dno zna\u010dilno povezavo med uporabo selektivnih zaviralcev ponovnega privzema serotonina (SSRI) (HR 1,34; 95 % CI 1,18\u20131,52) in venlafaksina (HR 1,35; 95 % CI 1,07\u20131,70) ter pove\u010danim tveganjem za razvoj manije ali bipolarne motnje.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Zaklju\u010dek:<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Rezultati \u0161tudije ka\u017eejo, da je zdravljenje z antidepresivi pri posameznikih z depresijo povezano s pove\u010danim tveganjem za kasnej\u0161i razvoj manije ali bipolarne motnje. To poudarja pomen skrbnega ocenjevanja tveganja za manijo pred za\u010detkom zdravljenja z antidepresivi pri bolnikih z depresijo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vir: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4679886\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4679886\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u010clanek z naslovom &#8220;Do antidepressants increase the risk of mania and bipolar disorder in people with depression? A retrospective electronic case register cohort study&#8221; (PMCID: PMC4679886) preu\u010duje povezavo med uporabo antidepresivov in kasnej\u0161im razvojem manije ali bipolarne motnje pri posameznikih z depresijo. Klju\u010dne ugotovitve: Zaklju\u010dek: Rezultati \u0161tudije ka\u017eejo, da je zdravljenje z antidepresivi pri posameznikih [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":542,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-541","post","type-post","status-publish","format-standard","has-post-thumbnail","category-povzetki"],"_links":{"self":[{"href":"https:\/\/madinslovenia.org\/index.php?rest_route=\/wp\/v2\/posts\/541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/madinslovenia.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/madinslovenia.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/madinslovenia.org\/index.php?rest_route=\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/madinslovenia.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=541"}],"version-history":[{"count":2,"href":"https:\/\/madinslovenia.org\/index.php?rest_route=\/wp\/v2\/posts\/541\/revisions"}],"predecessor-version":[{"id":545,"href":"https:\/\/madinslovenia.org\/index.php?rest_route=\/wp\/v2\/posts\/541\/revisions\/545"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/madinslovenia.org\/index.php?rest_route=\/wp\/v2\/media\/542"}],"wp:attachment":[{"href":"https:\/\/madinslovenia.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/madinslovenia.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/madinslovenia.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}